New investigate confirms HRT helps sentinel off colon cancer

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NEW YORK (Reuters Health) - Hormone deputy care (HRT) cuts a woman"s risk of building colon cancer, new examine confirms.

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Millions of women stopped receiving HRT when a Women"s Health Initiative examine showed in 2002 that the hormones lifted the risk of stroke, heart disease and breast cancer.

But the Women"s Health Initiative had additionally found that HRT stable opposite colon cancer. Some studies have additionally referred to that verbal contraceptives competence revoke the risk of the disease, whilst the actuality that women are at revoke risk of colon cancer than men additionally hints at a hormonal purpose in disease risk.

To examine ties in in in between HRT and colon cancer further, Dr. Millie D. Long of the University of North Carolina at Chapel Hill and her colleagues suited 443 women diagnosed in in in between 2001 and 2006 with distal large bowel cancer (meaning tumors at the far finish of the colon and the rectum) to 405 full of health carry out women. The normal age of the examine participants was around 63.

Long"s group found that women who had ever used HRT were at half the risk of this sort of colon cancer compared to women who"d never used hormone replacement, and the longer a lady was on HRT, the revoke the risk.

For example, women who used hormones for less than 4 years cut their colon cancer risk by about one-quarter; 4 to eight years of HRT cut risk by a third; 9 to fourteen years of make make make use of of halved risk; and fifteen years or some-more of HRT marked down risk by two-thirds. The goods were the same for African-American women and white women.

However, there was no attribute in in in between verbal preventive make make make use of of and colon cancer risk, the examine group reports in the American Journal of Gastroenterology.

Long-term hormone care is no longer endorsed for postmenopausal women, Long and her group note, nonetheless it is still infrequently prescribed on a short-term basement to assistance women with menopausal symptoms such as prohibited flashes. The vital dump off in distal large bowel cancer in new years could have been associated to drawn out make make make use of HRT, the researchers say.

More examine is indispensable to establish if HRT"s protecting goods endure after women stop receiving hormones, the researchers add, or either there competence be a "rebound" outcome with some-more pre-cancerous polyps building after a lady halts

HRT.

"It might turn critical in the destiny to tailor timing of women"s colorectal screening formed on relinquishment of hormonal therapy," Long and her colleagues conclude.

SOURCE: The American Journal of Gastroenterology, online Mar 30, 2010.

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